منابع مشابه
Phenotypic screens as a renewed approach for drug discovery.
The significant reduction in the number of newly approved drugs in the past decade has been partially attributed to failures in discovery and validation of new targets. Evaluation of recently approved new drugs has revealed that the number of approved drugs discovered through phenotypic screens, an original drug screening paradigm, has exceeded those discovered through the molecular target-base...
متن کاملPhenotypic Drug Discovery with High Content Screening
Drug discovery in its early history used to be conducted mainly in a target-agnostic fashion, focusing on qualitative readouts from a living system -cells, tissue, or organisms -and asking the question, ‘Did this entity affect the phenotype?’. With the rise of molecular biology in the early 1980s and an ever more powerful genomics toolkit from the 1990s, there was a marked shift away from pheno...
متن کاملEthnobotany, Ethnopharmacology and Drug Discovery
This manuscript is a review of a number of ethnobotany and ethnopharmacology texts and papers in order to arrive at current understanding and scope of ethnobotany and ethnopharmacology. It includes either a brief definition of both fields and presenting some examples on them. Also it has a glimpse on the geographical coverage of research works throughout the world, important issue of prope...
متن کاملA novel phenotypic screening platform targeting chronic pain drug discovery
Chronic pain is a disease area with a significant and unmet need for improved treatments. However, due to the complex nature of pain transduction, pain is a notoriously difficult area for drug discovery, where conventional target-based efforts have largely failed to produce new drugs. In this whitepaper, we present a novel phenotypic screening platform based on our proprietary Cellaxess® Elektr...
متن کاملPhenotypic taxonomy and metabolite profiling in microbial drug discovery.
Microorganisms and in particular actinomycetes and microfungi are known to produce a vast number of bioactive secondary metabolites. For industrially important fungal genera such as Penicillium and Aspergillus the production of these compounds has been demonstrated to be very consistent at the species level. This means that direct metabolite profiling techniques such as direct injection mass sp...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2009
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.8.1.7330